Melatonin- and Ferulic Acid-Based HDAC6 Selective Inhibitors Exhibit Pronounced Immunomodulatory Effects

Autor:	Feng, He, C James, Chou, Matthias, Scheiner, Eleonora, Poeta, Natalia, Yuan Chen, Sandra, Gunesch, Matthias, Hoffmann, Christoph, Sotriffer, Barbara, Monti, Tangui, Maurice, Michael, Decker
Rok vydání:	2021
Předmět:	Male Coumaric Acids Histone Deacetylase 6 Tryptamines Histone Deacetylase Inhibitors Molecular Docking Simulation Mice Structure-Activity Relationship Neuroprotective Agents Alzheimer Disease Catalytic Domain Animals Immunologic Factors Cell Line Transformed Melatonin
Zdroj:	Journal of medicinal chemistry. 64(7)
ISSN:	1520-4804
Popis:	The structures of melatonin and ferulic acid were merged into tertiary amide-based histone deacetylase 6 (HDAC6) inhibitors to develop multi-target-directed inhibitors for neurodegenerative diseases to incorporate antioxidant effects without losing affinity and selectivity at HDAC6. Structure-activity relationships led to compound
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::318f23c7d12113691eaa9ef111cb5032 https://pubmed.ncbi.nlm.nih.gov/33769811 Zobrazit plný text záznamu