| Autor: |
R E, Gammans, R D, Sehon, M W, Anders, P E, Hanna |
| Rok vydání: |
1978 |
| Předmět: |
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| Zdroj: |
Drug metabolism and disposition: the biological fate of chemicals. 6(3) |
| ISSN: |
0090-9556 |
| Popis: |
Hamster liver microsomes catalyze the N-hydroxylation of the 4'-OCH3, 4'-OCH2CH3, 4'-O(CH2)2CH3, and 4'-O(CH2)3CH3 analogs of trans-4-acetamidostilbene. Other metabolites which were identified were the O-deethylation product of the 4'-OCH2CH3 analog as well as the alpha,beta-epoxides of the 4'-OCH2CH3 and 4'-O(CH2)2CH3 compounds and the (omega-1)-hydroxylation product of trans-4'-n-butoxy-4-acetamidostilbene. The kinetics of metabolism of the 4'-O(CH2)3CH3 analog were determined, but the rates of formation of the metabolites of the other members of the series were not linearly related to substrate concentration. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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