3,28-Di-O-(dimethylsuccinyl)-betulin isomers as anti-HIV agents

Autor:	Y, Kashiwada, J, Chiyo, Y, Ikeshiro, T, Nagao, H, Okabe, L M, Cosentino, K, Fowke, K H, Lee
Rok vydání:	2001
Předmět:	Inhibitory Concentration 50 Structure-Activity Relationship Isomerism Therapeutic Equivalency Anti-HIV Agents HIV-1 Succinic Acid Combinatorial Chemistry Techniques Humans Lymphocytes Cell Division Triterpenes Cell Line
Zdroj:	Bioorganicmedicinal chemistry letters. 11(2)
ISSN:	0960-894X
Popis:	Four isomers of 3,28-di-O-(dimethylsuccinyl)-betulin were prepared and evaluated for anti-HIV activity against HIV-1 replication in H9 lymphocyte cells. 3-O-(3',3'-Dimethylsuccinyl)-28-O-(2", 2"-dimethvlsuccinyl)-betulin (11) was the most potent anti-HIV compound with an EC5, value of 0.00087 microM and a TI value of 42,400.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::3184092f53622648b27433d1f9c93597 https://pubmed.ncbi.nlm.nih.gov/11206454 Zobrazit plný text záznamu Full Text from ScienceDirect