| Autor: |
V V, Pogodina, M P, Frolova, G V, Malenko, G I, Fokina, L S, Levina, L L, Mamonenko, G V, Koreshkova, N M, Ralf |
| Rok vydání: |
1981 |
| Předmět: |
|
| Zdroj: |
Acta virologica. 25(6) |
| ISSN: |
0001-723X |
| Popis: |
Sixty-seven Macaca rhesus monkeys were inoculated with 2 mutants and 3 virulent strains of tick-borne encephalitis (TBE) virus including strains isolated from patients with a chronic form of TBE. A model of the clinical course of acute, subacute, and chronic encephalitis was produced by intracerebral inoculation and that of asymptomatic infection was produced by subcutaneous inoculation [with or without administration of cyclophosphane (CP)]. Virus persistence developed after inoculation with all the strains, after non-fatal encephalitis and inapparent infection irrespective of CP administration. In monkeys recovering from encephalitis the virus persisted for at least 783 days. After asymptomatic infection, it persisted for 302 days; neither virus nor virus-specific antigen was detected at 356, 367, and 620 days. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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