[Epidemiology, species, antifungal resistance and outcome of candidemia in a university hospital in Buenos Aires, Argentina for 16 years]
Autor: | Iris Nora, Tiraboschi, Natalia Cintia, Pozzi, Luciana, Farías, Susana, García, Norma Beatriz, Fernández |
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Rok vydání: | 2016 |
Předmět: |
Adult
Male Antifungal Agents Time Factors Adolescent Argentina Microbial Sensitivity Tests Hospitals University Young Adult Age Distribution Drug Resistance Fungal Risk Factors Central Venous Catheters Humans Child Fluconazole Aged Candida Retrospective Studies Aged 80 and over Cross Infection Incidence Infant Newborn Candidemia Infant Middle Aged Child Preschool Multivariate Analysis Female |
Zdroj: | Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia. 34(5) |
ISSN: | 0717-6341 |
Popis: | The epidemiology of candidemia vary by region.To determine the epidemiology of candidemia in a hospital for 16 years.Episodes of candidemia occurred in the Hospital de Clinicas of Buenos Aires were reviewed, from 01/01/98 to 31/12/13.374 episodes of candidemia were identified. The incidence was 2.21/1,000 discharges and increased from 1.96 (1998-2005) to 2.25 (2006-2013) (p = 0.023). Candidemia was diagnosed: 5.4% in neonates, 1.7% in infants, 6.5% in children, 31.8% in adults and 52.7% in elderly adults over 64 years old. The episodes were caused by C. albicans (40.9%), C. parapsilosis (21.7%), C. tropicalis (15.5%), C. glabrata (13.9%), other species of Candida (5.1%) and more than one species of Candida (2.9%). The 5.3% of the isolates were resistant to fluconazole. 74% of patients were treated. Initial treatments were with fluconazole (70.3%), amphotericin B deoxycholate (25%), echinocandins or lipidic amphotericin (4,7%). The 81% of central venous catheters were taken off. Mortality rate was of 47.9%, but in the elderly adults was of 60.8%.The incidence of candidemia showed an increase over the years. It was higher in the elderly adults, being the group with worse outcomes. |
Databáze: | OpenAIRE |
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