| Popis: |
Hind footpads of mice of inbred strains were injected with horseradish peroxidase (PO) in Freund's complete adjuvant (FCA) and the response of the antibody-forming cells (AFC) in their popliteal lymph nodes was measured. Marked strain differences were found after the first injection and three types of responder strains were defined: high responders, with H-2s, H-2a and H-2b haplotypes, low responders, with the H-2d haplotype and an intermediate type of responder, observed in mice of the H-2k and H-2q haplotypes. After a second injection of PO in FCA, strain differences in the response disappeared and all strains responded equally well. F1 hybrids from high and intermediate or low responders gave a mean AFC response between the two parental responses. |
