Critical Role for the Microbiota in CX
| Autor: | Myunghoo, Kim, Carolina, Galan, Andrea A, Hill, Wan-Jung, Wu, Hannah, Fehlner-Peach, Hyo Won, Song, Deborah, Schady, Matthew L, Bettini, Kenneth W, Simpson, Randy S, Longman, Dan R, Littman, Gretchen E, Diehl |
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| Rok vydání: | 2017 |
| Předmět: |
Inflammation
Male Antigen Presentation CX3C Chemokine Receptor 1 Th1 Cells Inflammatory Bowel Diseases T-Lymphocytes Regulatory Bacterial Adhesion Gastrointestinal Microbiome Interleukin-10 Disease Models Animal Mice RAW 264.7 Cells Immune Tolerance Animals Homeostasis Female Intestinal Mucosa Immunity Mucosal Mononuclear Phagocyte System |
| Zdroj: | Immunity. 49(1) |
| ISSN: | 1097-4180 |
| Popis: | The intestinal barrier is vulnerable to damage by microbiota-induced inflammation that is normally restrained through mechanisms promoting homeostasis. Such disruptions contribute to autoimmune and inflammatory diseases including inflammatory bowel disease. We identified a regulatory loop whereby, in the presence of the normal microbiota, intestinal antigen-presenting cells (APCs) expressing the chemokine receptor CX |
| Databáze: | OpenAIRE |
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