Mannoproteins from Candida albicans elicit a Th-type-1 cytokine profile in human Candida specific long-term T cell cultures

Autor:	A, La Sala, F, Urbani, A, Torosantucci, A, Cassone, C M, Ausiello
Rok vydání:	1996
Předmět:	Antigens Fungal Membrane Glycoproteins Th1 Cells Lymphocyte Activation Methylprednisolone Polymerase Chain Reaction Interferon-gamma Gene Expression Regulation Candida albicans Humans Interleukin-2 Leukocyte Common Antigens RNA Messenger Immunologic Memory Cells Cultured
Zdroj:	Journal of biological regulators and homeostatic agents. 10(1)
ISSN:	0393-974X
Popis:	Since T lymphocytes are active producers of regulatory cytokines, long-term T cell cultures (LTTC) specific for a major mannoproteic antigen (MP) of Candida albicans from peripheral blood mononuclear cells (PBMC) of healthy donors were generated and their cytokine profile studied. LTTC consisted of an expanded CD3CD4 T-helper (Th) populations, with a high proportion of CD45R0 T memory cells. Stimulation of LTTC by MP induced a Th-1 type cytokine profile, as indicated by the presence of IFN-gamma and the absence of IL-5 (both as mRNA and protein) in cell cultures and supernatants. These results suggest a predominant Th1 response elicited by C. albicans mannoprotein antigen in human PBMC.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::30c5390be6f22feb5df8e44d69ab53b5 https://pubmed.ncbi.nlm.nih.gov/9049775 Zobrazit plný text záznamu