Investigation of a cluster of multiple sclerosis in two elementary school cohorts

Autor:	Judy P, Henry, Dhelia M, Williamson, Randolph, Schiffer, Laurie, Wagner, Jeffrey, Shire, Matthew, Garabedian
Rok vydání:	2007
Předmět:	Adult Male Multiple Sclerosis Environmental Exposure Middle Aged Texas Cohort Studies Heavy Metal Poisoning Metals Heavy Surveys and Questionnaires Metallurgy Prevalence Cluster Analysis Humans Female Child Students Aged Hair Retrospective Studies
Zdroj:	Journal of environmental health. 69(10)
ISSN:	0022-0892
Popis:	The authors investigated a cluster of multiple sclerosis (MS) among people who had attended two elementary schools in El Paso, Texas, from 1948 through 1970. The community was concerned about the possibility of childhood exposure to heavy metals from a large nearby smelter because historical environmental and biological sampling data demonstrated the potential for study cohort members to have been exposed to heavy metals during their pre-adolescent years. One cohort had no reported cases of MS. In the second cohort, 22 members self-reported a diagnosis of MS, and 16 of these cases were confirmed as MS by an independent board-certified neurologist. The crude MS prevalence estimate was 411 per 100,000 (95 percent confidence interval [CI] = 197-603), Prevalence estimates from four different populations were used for calculation of standardized morbidity ratios (SMRs). At the extremes, the study cohort represents a deficit of cases (SMR= 0.9; 95 percent CI = 0.51-1.44) or a four-fold excess (SMR = 4.0; 95 percent Cl = 2.29-6.5).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::30c1a8cd96dc65f321c4a52657fa801a https://pubmed.ncbi.nlm.nih.gov/17583294 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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