| Autor: |
Yun, Huang, Guizhu, Dai, Zongchen, Feng, Chengfa, Lu, Bei, Cheng, Qiufen, Wang, Fuding, Nie, Jingdong, Li |
| Rok vydání: |
2003 |
| Předmět: |
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| Zdroj: |
Chinese medical journal. 116(11) |
| ISSN: |
0366-6999 |
| Popis: |
To investigate the effect of micronized fenofibrate on vascular endothelial function in patients with hypertriglyceridemia.Using high-resolution ultrasound, we measured flow- and nitroglycerin-induced dilatation of the brachial artery in 30 patients with hypertriglyceridemia before and after treatment with micronized fenofibrate at a dose of 200 mg once daily for 4 weeks. Simultaneously, both serum lipid and plasma endothelin (ET) levels were determined.After micronized fenofibrate therapy, serum triglyceride (TG) levels decreased significantly (P0.05). Plasma ET levels also decreased markedly [(82.66 +/- 15.46) microg/L vs. (106.22 +/- 19.16) microg/L, P0.001]. Flow-induced vasodilatation was much improved (11.0% +/- 9.0% vs 2.7% +/- 2.0%, P0.01). However, no significant changes in vasodilatation occurred in response to nitroglycerin (16.2% +/- 6.0% vs 15.0% +/- 5.0%, P0.05) in patients with hypertriglyceridemia.Micronized fenofibrate can improve impaired endothelium-dependent vasodilatation in patients with hypertriglyceridemia. Improving endothelial function may also be the mechanism responsible for the beneficial effects of micronized fenofibrate. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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