Blastic mantle cell lymphoma associated with Burkitt-type translocation and hypodiploidy

Autor:	U N, Vaishampayan, A N, Mohamed, M C, Dugan, R E, Bloom, M, Palutke
Rok vydání:	2001
Předmět:	Chromosomes Human Pair 14 Male Ploidies Chromosomes Human Pair 1 Chromosomes Human Pair 11 Humans Lymphoma Mantle-Cell Burkitt Lymphoma Chromosomes Human Pair 19 In Situ Hybridization Fluorescence Translocation Genetic Aged Chromosomes Human Pair 8
Zdroj:	British journal of haematology. 115(1)
ISSN:	0007-1048
Popis:	Two elderly men with stage IV mantle cell lymphoma (MCL) rapidly developed a leukaemic phase with unusually high blast counts that proved fatal. One lymph node biopsy showed diffuse MCL, the other blastic morphology. In addition to t(11;14), there were t(8;14) and t(1;19) in case 1 and dup(8)(q24q13) in case 2. Fluorescence in situ hybridization revealed genomic fusion of IgH/MYC genes in case 1 and an extra copy of C-MYC gene in case 2. The genomic alteration of C-MYC oncogene is probably implicated in the blastic transformation and aggressive behaviour of the disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::30a6b6bbed286e2f6e03ada4cfd05125 https://pubmed.ncbi.nlm.nih.gov/11722412 Zobrazit plný text záznamu Plný text