| Autor: |
Debora, Laker, Frederik, Tolle, Michael, Stegen, Marco, Heerdegen, Rüdiger, Köhling, Timo, Kirschstein, Jakob, Wolfart |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Neuroscience. 467 |
| ISSN: |
1873-7544 |
| Popis: |
The slow afterhyperpolarizing potential (sAHP) can silence a neuron for hundreds of milliseconds. Thereby, the sAHP determines the discharge behavior of many types of neurons. In dentate granule cells (DGCs), serving as a filter into the hippocampal network, mostly tonic or adapting discharge properties have been described. As under standard whole-cell recording conditions the sAHP is inhibited, we reevaluated the intrinsic functional phenotype of DGCs and the conductances underlying the sAHP, using gramicidine-perforated patch-clamp technique. We found that in 97/113 (86%) of the DGCs, a burst of action potentials (APs) to excitation ended by a large sAHP, despite continued depolarization. This result suggests that burst-like firing is the default functional phenotype of DGCs and that sAHPs are important for it. Indeed, burst-like firing DGCs showed a significantly higher sAHP-current (I |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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