Drug Resistance of Mouse Somatic Cells to Rifampicin in Experimental Tuberculosis

Autor:	B V, Nikonenko, I V, Bocharova, L N, Lepekha
Rok vydání:	2020
Předmět:	Mice Antitubercular Agents Drug Resistance Isoniazid Animals Tuberculosis Mycobacterium tuberculosis Rifampin
Zdroj:	Bulletin of experimental biology and medicine. 171(1)
ISSN:	1573-8221
Popis:	We have demonstrated that long-term exposure of intact mice to rifampicin (6 months) induces resistance to this drug, which manifested in inability of rifampicin to suppress the growth of Mycobacterium tuberculosis in the lungs and spleen during subsequent infection. It the same time, isoniazid is still effective in these mice. In this case, the phenomenon of somatic resistance to rifampicin in mice was observed if the treatment was started in a short period (within 4 days) after infection with M. tuberculosis. If the interval between infection and rifampicin administration was longer (3 weeks), the resistance disappeared.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::3049dd0fc41e6453705f1e50644db8da https://pubmed.ncbi.nlm.nih.gov/34050415 Zobrazit plný text záznamu Full text from SpringerLink