Penicillin allergy de-labeling: Opportunities for implementation and dissemination

Autor: Upeka, Samarakoon, John, Accarino, Alysse, Wurcel, Jordon, Jaggers, Allen, Judd, Kimberly, Blumenthal
Rok vydání: 2022
Zdroj: Annals of allergy, asthmaimmunology : official publication of the American College of Allergy, Asthma,Immunology.
ISSN: 1534-4436
Popis: Although existing as a safety measure to prevent iatrogenic harm, unconfirmed penicillin allergy labels have a negative impact on personal and public health. One downstream effect of unconfirmed penicillin allergy is the continued emergence and transmission of resistant bacteria and associated healthcare cost. Recognizing the consequences of inaccurate penicillin allergy labels, professional and public health organizations have started promoting the adoption of proactive penicillin allergy evaluations, with the ultimate goal of removing the penicillin allergy label when the allergy is disproved, also known as penicillin allergy "de-labeling." A penicillin allergy evaluation includes a comprehensive allergy history often followed by skin testing and/or drug challenge procedures. Currently, penicillin allergy de-labeling is largely carried out by allergy specialists in outpatient settings. Penicillin allergy de-labeling is performed on inpatients, albeit rarely, at the time of need, as a point-of-care procedure. Access to penicillin allergy evaluation services is limited. Recent studies demonstrate the feasibility of expanding penicillin allergy evaluations and de-labeling to internists, pediatricians, emergency medicine physicians, infectious diseases specialists, and clinical pharmacists. Reducing the impact of mislabeled penicillin allergy will require comprehensive efforts and new investments. In this review, we summarize the current practices of penicillin allergy de-labeling and discuss expansion opportunities for penicillin allergy de-labeling as quality improvement.
Databáze: OpenAIRE