Evaluation of formalin inactivated V3526 virus with adjuvant as a next generation vaccine candidate for Venezuelan equine encephalitis virus, Shannon S. Martin
Autor: | Martin, Shannon S., Bakken, Russell R., Lind, Cathleen M., Garcia, Patricia, Jenkins, Erin, Glass, Pamela J., Parker, Michael D., Hart, Mary Kate, Fine, Donald L. |
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Jazyk: | angličtina |
Rok vydání: | 2010 |
Předmět: |
Mice
Inbred BALB C Injections Subcutaneous Encephalomyelitis Venezuelan Equine Viral Vaccines Antibodies Viral Antibodies Neutralizing Injections Intramuscular Survival Analysis Article Encephalitis Virus Venezuelan Equine Mice Adjuvants Immunologic Vaccines Inactivated Formaldehyde Animals Female Disinfectants |
Popis: | V3526, a genetically modified strain of Venezuelan equine encephalitis virus (VEEV), was formalin inactivated for evaluation as a next generation vaccine candidate for VEEV. In this study, we tested formalin-inactivated V3526 (fV3526) with and without adjuvant for immunogenicity and efficacy in BALB/c mice and results were compared to the existing inactivated VEEV vaccine, C84. Mice were vaccinated intramuscularly (IM) or subcutaneously (SC) with fV3526 formulations and challenged with VEEV IAB Trinidad donkey (VEEV TrD) strain by SC or aerosol exposure. Efficacy following SC or aerosol challenge was not significantly different between the fV3526 formulations or compared to C84 despite C84 being administered in more doses and higher concentration of viral protein per dose. These data support further evaluation of fV3526 formulations as a next generation VEEV vaccine. |
Databáze: | OpenAIRE |
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