| Autor: |
Joydip, Ghosh, Sondipon, Chakraborty, Somaditya, Dey, Debarati, Mukherjee, Biswajyoti, Sarkar, Suvadip, Mallick, Aritri, Dutta, Tanmoy, Dutta, Soumen, Bhattacharjee, Narayan, Ghorai, Chiranjib, Pal |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Acta parasitologica. 66(4) |
| ISSN: |
1896-1851 |
| Popis: |
In the present perspective, emergence of resistant strains of Leishmania donovani and severe side effects resulting from the use of conventional anti-leishmanial therapies present an urgent need for developing novel agents against this parasite. We have explored the effectiveness of secondary plant metabolites as alternative choices in the treatment for visceral leishmaniasis (vl).The plant Parthenium hysterophorus L. (Asteraceae) was collected from the West Bengal State University Campus, Barasat, West Bengal, India. The leaves of this plant were extracted by different solvents, such as ethyl acetate, water, petroleum ether and hexane. Gas chromatography-mass spectrometry (GC-MS) analysis was also carried out for the identification of compounds in the hexane soluble fraction (PHFd) with substantial anti-leishmanial activities. The antipromastigote activity and cytotoxicity of this fraction were evaluated by the tetrazolium MTT assay. Other biochemical and physiological parameters were studied by microscopic observation and flow cytometric analyses.PHFd showed considerable activity against L. donovani promastigotes (ICThis study provides the basis for additional phytochemical and pharmacological studies on the antiprotozoal applications of P. hysterophorus. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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