[Inhibitory effect of ellipticine (dimethyl-5,11-(6H) pyrido (4,3-b) carbazole on the induction of liver cancer by BT6 (N,N-dimethyl-p-(benzothiazolylazo) analine) and its effect on the levels of cytochrome P450 and arginase activity]

Autor:	R, Truhaut, H, Dophuoc, T P, Cao, J C, Gak, P, Jacquignon, G N, Ba
Jazyk:	francouzština
Rok vydání:	1976
Předmět:	Male Thiazoles p-Dimethylaminoazobenzene Alkaloids Time Factors Arginase Cytochrome P-450 Enzyme System Liver Liver Neoplasms Animals Ellipticines Neoplasms Experimental Rats
Zdroj:	Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles. 282(12)
Popis:	Under the conditions of our tests, ellipticine inhibits remarkably the carcinogenic action of BT6 on the liver, characterized, in particular, by the swiftness of its outbreak. Under the influence of this carcinostatic compound, a considerable activation of liver metabolism is observed, resulting in an hyperproduction of cytochrome P450, while the arginase capital is restored after an appreciable fall, as if ellipticine played a favourable part in the safeguard of this enzyme, recognized as one of the targets of liver carcinogens. The relationships between various effects of ellipticine are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::301bbc87082d7f529329e2c8086be985 https://pubmed.ncbi.nlm.nih.gov/819169 Zobrazit plný text záznamu