Diabetic complications and the genetics of signal transduction. A study of retinopathy in NIDDM

Autor:	N, Lucarini, N, Bottini, E, Antonacci, P, Borgiani, G, Faggioni, F, Gloria-Bottini
Rok vydání:	1997
Předmět:	Adult Aged 80 and over Male Diabetic Retinopathy Diabetes Mellitus Type 2 Adenosine Deaminase Acid Phosphatase Humans Regression Analysis Female Middle Aged Aged Signal Transduction
Zdroj:	Disease markers. 13(3)
ISSN:	0278-0240
Popis:	Cytosolic low molecular weight acid phosphatase (ACP1) is a high polymorphic phosphotyrosine-protein-phosphatase involved in signal transduction. In NIDDM subjects we have found that ACP1 genotype is a highly significant predictor of retinopathy, suggesting that genetic variability of signal transduction may have an important role in the susceptibility to this complication. Adenosine deaminase, ABO blood groups and several clinical variables have been also considered. The results point out the importance of interactions between genetic systems. Among non-genetic variables dislipidemia and treatment with insulin are significantly associated with retinopathy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::2ff4bc94dbb3d581299b60b54e94afae https://pubmed.ncbi.nlm.nih.gov/9405929 Zobrazit plný text záznamu Plný text