In vitro characterization of polyorthoester microparticles containing bupivacaine

Autor:	Jone-Shin, Deng, Luk, Li, Youqin, Tian, Eric, Ginsburg, Matthew, Widman, Alecia, Myers
Rok vydání:	2003
Předmět:	Chemistry Pharmaceutical Polyesters Particle Size Bupivacaine Microspheres
Zdroj:	Pharmaceutical development and technology. 8(1)
ISSN:	1083-7450
Popis:	Laboratory-scale spray-congealing equipment was utilized to fabricate injectable microparticles consisting of polyorthoester and bupivacaine. Operating conditions for the spray-congealing process were optimized to produce microparticles with the desired shape and particle size to yield acceptable syringeability and injectability. Characterizations were performed to determine the chemico-physical properties of polyorthoester before and after microparticle fabrication. Microparticles with different drug loadings and comparable particle sizes were produced, and their in vitro drug-release profiles were determined. The in vitro drug release of microparticles with a high drug loading was markedly faster than those with a low drug loading. This is partially attributed to a more significant initial burst-drug release of the microparticles with a high drug loading. The microparticles have demonstrated the potential to be used for long-acting postsurgery pain management by local injection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::2fb25cf3b94bb5975ed4e00fad50ed0a https://pubmed.ncbi.nlm.nih.gov/12665195 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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