| Autor: |
Edris, Valadbeigi, Shahram, Ghodsi |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Iranian Journal of Pharmaceutical Research : IJPR |
| ISSN: |
1735-0328 |
| Popis: |
A series of N-[2-(8-metoxy-2H-chromen-2-one)ethyl] piperazinyl quinolones containing a carbonyl related functional groups (oxo or oxyimino) on the ethyl spacer of coumarin and piperazin rings was synthesized and studied for their antibacterial and antifungal activities . The synthesis of compounds (6a-6l) was achieved through the versatile and efficient synthetic route that involved reaction of quinolones with appropriately α- bromo ketone or α- bromo oxime derivatives (2, 2a-c). The structures of the new compounds were confirmed by IR, Mass, 1H-NMR and 13C-NMR spectra. More good activities against gram-positive and gram-negative are shown in all compounds. The antifungal data reveals that all compounds have shown weak antifungal activity as compared to Nistatin. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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