| Autor: |
C F, Nicoletti, C, Cortes-Oliveira, N Y, Noronha, M A S, Pinhel, W S, Dantas, A, Jácome, J S, Marchini, B, Gualano, A B, Crujeiras, C B, Nonino |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
European journal of clinical nutrition. 74(9) |
| ISSN: |
1476-5640 |
| Popis: |
We aimed to investigate the effects of short-term hypocaloric diet-induced weight loss on DNA methylation profile in leukocytes from women with severe obesity.Eleven women with morbid obesity (age: 36.9 ± 10.3 years; BMI: 58.5 ± 10.5 kg/mDietary intervention changed the methylation levels at 16,064 CpG sites. These CpGs sites were related to cancer, cell cycle-related, MAPK, Rap1, and Ras signaling pathways. However, regardless of hypocaloric intervention, a group of 878 CpGs (related to 649 genes) remained significantly altered in obese women when compared with normal-weight women. Pathway enrichment analysis identified genes related to the cadherin and Wnt pathway, angiogenesis signaling, and p53 pathways by glucose deprivation.A short-term hypocaloric intervention in patients with severe obesity partially restored the obesity-related DNA methylation pattern. Thus, the full change of obesity-related DNA methylation patterns could be proportional to the weight-loss rate in these patients after dietary interventions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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