| Autor: |
Hinta, Meijerink, Agnes R, Indrati, Suharyani, Soedarmo, Fitri, Utami, Cor A J, de Jong, Bachti, Alisjahbana, Reinout, van Crevel, Rudi, Wisaksana, Andre J A M, Van der Ven |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
AIDS (London, England). 29(3) |
| ISSN: |
1473-5571 |
| Popis: |
Opioid use may affect HIV infection through altered expression of HIV co-receptors. This was examined in Indonesia among antiretroviral therapy-naive HIV patients, many of whom use drugs. C-C chemokine receptor type 5 (CCR5) expression on CD4+ cells was higher in heroin (P = 0.007), methadone (P = 0.024) and former opioid users (P = 0.003) compared to nonusers, whereas production of RANTES and other CCR5 ligands was similar or lower. This suggests that opioids can affect HIV susceptibility through up-regulation of CCR5 or down-regulation of its ligands. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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