| Autor: |
Shi-liang, Tu, Jian-hua, Yuan, Gao-li, Deng, Zhong-sheng, Zhao, Ting-yang, Hu, Quan-jin, Dong, Hong-feng, Cao, Zai-yuan, Ye |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery. 10(2) |
| ISSN: |
1671-0274 |
| Popis: |
To study the effects of prophylactic intra-iliac and hepatic arterial infusion chemotherapy on pelvic recurrence and liver metastasis after radical resection for rectal cancer.Eighty-four rectal cancer patients,undergone radical resection on Dukes stage B or C,were randomly assigned to postoperative intra-iliac and hepatic arterial infusion chemotherapy group(group I) and routine vein chemotherapy group(group II). Five-year survival and recurrence rates were compared between the two groups.Among the 84 rectal cancer patients with radical resection, the 5-year liver metastasis and pelvic recurrence rates were 30.2% (13/43) and 18.6% (8/43) respectively in group II, 17.1% (7/41) and 9.8% (4/41) in group I, the difference was significant between 2 groups (chi(2)=4.31, P0.05). The mean tumor-free survival time was 26.2 months in group I and 15.8 months in group II (t=5.05, P0.01), the difference was significant (t=5.05, P0.01). The five-year survival rate in group I (65.9%) was significantly higher than that in group II (56.5%) (u=8.86, P0.01). Cox multivariate analysis showed that, compared with those in group II, the relative risks of pelvic recurrence and liver metastasis in group I decreased 20% (coefficient of relative risk: 0.7959), and the five-year mortality also decreased 20% (coefficient of relative risk: 0.8034).Prophylactic intra-iliac and hepatic arterial infusion chemotherapy can reduce the rates of pelvic recurrence and liver metastasis after radical resection of rectal cancer. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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