The prognostic value of abnormally expressed lncRNAs in prostatic carcinoma
| Autor: | Wu, Xian-Lan, Zhang, Ji-Wang, Li, Bai-Song, Peng, Shu-Sheng, Yuan, Yong-Qiang |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Prostatic Neoplasms Middle Aged prostate cancer Prognosis survival Risk Assessment Survival Analysis Disease-Free Survival meta-analysis Gene Expression Regulation Neoplastic lncRNA Humans Neoplasm Invasiveness RNA Long Noncoding Systematic Review and Meta-Analysis Research Article Aged Neoplasm Staging |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Background: Several long noncoding RNAs (lncRNAs) are abnormally expressed in prostate cancer (PCa), suggesting that they could serve as novel prognostic markers. The current meta-analysis was undertaken to better define the prognostic value of various lncRNAs in PCa. Methods: The PubMed, Embase, Medline, and Cochrane Library databases were systematically searched up to February 19, 2017, to retrieve eligible articles. Outcomes analyzed were biochemical recurrence-free survival (BRFS), overall survival (OS), metastasis-free survival (MFS), and prostate cancer-specific survival (PCSS). Pooled hazard ratios (HRs) and 95% confidence intervals (95%CIs) were calculated using fixed-effects or random-effects models. Results: A total of 10 studies, evaluating 11 PCa-related lncRNAs, were included in the meta-analysis. Pooled results indicate that the abnormal expression of candidate lncRNAs in PCa samples predicted poor BRFS (HR: 1.67, 95%CI: 1.37–2.04, P |
| Databáze: | OpenAIRE |
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