[Cytokines and remodeling of the heart in patients with congestive heart failure]
| Autor: | Beata, Jołda-Mydłowska, Piotr, Salomon |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Cardiomyopathy Dilated Male Radioimmunoprecipitation Assay Time Factors Heart Valve Diseases Myocardial Infarction Severity of Illness Index Catecholamines Natriuretic Peptide Brain Humans Aldosterone Aged Heart Failure Endothelin-1 Ventricular Remodeling Interleukin-6 Tumor Necrosis Factor-alpha Middle Aged Echocardiography Hypertension Cytokines Interleukin-2 Female Atrial Natriuretic Factor Biomarkers Follow-Up Studies Interleukin-1 |
| Zdroj: | Polskie Archiwum Medycyny Wewnetrznej. 109(1) |
| Popis: | Proinflammatory cytokines are capable of modulating cardiovascular function by a various mechanisms. The aim of the study was to evaluate the influence of the selected cytokines: tumor necrosis factor alpha (TNF-alpha), interleukin 1 (IL-1), interleukin 2 (IL-2), interleukin 6 (L-6), endothelin 1 (ET-1) on the remodeling of the heart in patients with congestive heart failure (1-year follow-up). The study was made in 45 patients with congestive heart failure treated in the Department of Cardiology. Of these, 31 were men aged from 44 to 77 and 14 were women aged from 48 to 79. Ischaemic heart disease was diagnosed in 22 patients and ischaemic heart disease and hypertension in 10 patients, dilated cardiomyopathy was diagnosed in 6 patients and postinflammatory cardiomyopathy in 7 patients. Blood samples for determination of TNF-alpha, IL-1, IL-2, IL-6, ET-1, aldosterone, catecholamines, brain natriuretic peptide (BNP) and atrial natriuretic peptide (ANP) levels were obtained prior to the treatment and in 3 and 6 and 12 month follow-up. At the same time were estimated: NYHA functional class, structure, systolic and diastolic left ventricle function of the heart using echocardiography and 24-hour ECG Holter monitoring (HR, supraventricular and ventricular arrhythmias). TNF-alpha, IL-1, IL-2, IL-6, ET-1, aldosterone, catecholamines, BNP and ANP plasma levels were determined with radioimmunological assay. In patients with progression of congestive heart failure (worsening of NYHA class and ejection fraction of left ventricle) the plasma concentrations of TNF-alpha and ET-1 significantly increased in following observations. In this group patients we determined a correlation between ejection fraction of the left ventricle and serum concentration of TNF-alpha and ET-1. In patients with improving of NYHA functional class and ejection fraction of left ventricle the plasma concentrations of cytokines were not altering. In all patients the plasma concentration of TNF-alpha correlated with ANP and BNP concentrations. |
| Databáze: | OpenAIRE |
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