| Autor: |
Wen-Bao, Hu, Xin, Wang, Zhi-Lin, Pang, Ran, Duan, Chun-Gu, Hong, Zheng-Zhao, Liu |
| Rok vydání: |
2022 |
| Zdroj: |
Animal models and experimental medicineREFERENCES. |
| ISSN: |
2576-2095 |
| Popis: |
Amyotrophic lateral sclerosis (ALS) is irreversible and fatal within 3-5 years, with limited options for treatment. It is imperative to develop a symptom-based treatment that may increase the survival of ALS patients and improve their quality of life. Inflammation status, especially elevated interleukin 1β (IL1β), has been reported to play a critical role in ALS progression. Our study determined that neutralizing circulating IL1β slows down the progression of ALS in an ALS mouse model.The ALS mouse model was developed by microinjection of lentivirus-carrying OPTNThe model revealed that neuroinflammation contributes to ALS progression. ALS mice exhibited elevated neuroinflammation and IL1β secretion. After anti-IL1β treatment, ALS mice revealed decreased neural cell death and astrogliosis and gained improved muscle strength and motor ability.Blocking IL1β is a promising strategy to slow down the progression of ALS. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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