[Renal denervation for treating hypertension: experience at the University Hospital in Lyon]
| Autor: | P-Y, Courand, R, Dauphin, O, Rouvière, V, Paget, F, Khettab, C, Bergerot, B, Harbaoui, G, Bricca, J-P, Fauvel, P, Lantelme |
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| Jazyk: | francouzština |
| Rok vydání: | 2014 |
| Předmět: |
Male
Blood Pressure Monitoring Ambulatory Middle Aged Kidney Denervation Peptide Fragments Body Mass Index Hospitals University Renal Artery Treatment Outcome Risk Factors Hypertension Natriuretic Peptide Brain Humans Female Hypertrophy Left Ventricular France Prospective Studies Essential Hypertension Biomarkers Aged Follow-Up Studies |
| Zdroj: | Annales de cardiologie et d'angeiologie. 63(3) |
| ISSN: | 1768-3181 |
| Popis: | We report the first experience of Lyon's university hospital regarding renal denervation to treat patients with resistant essential hypertension.Over a one-year period, 17 patients were treated (12 men, 5 women) with renal denervation. Baseline characteristics were as follows: age 56.5±11.5 years, BMI 33±5kg/m(2) and ambulatory blood pressure 157±16/87±13mmHg with 4.2±1.5 anti-hypertensive treatment.We did not observe intra-operative or early complications. After a median follow-up of 3 months and with the same anti-hypertensive treatment, office systolic blood pressure (SBP) and diastolic blood pressure (DBP) decrease respectively of 20±15 (P0.001) and 10±13mmHg (P=0.014) (n=17). After six months of follow-up, ambulatory blood pressure (ABPM) decrease of 17.5±14.9mmHg (P=0.027) for SBP and of 10.5±9.6mmHg (P=0.029) for DBP (n=6). Among these patients, five of them were controlled (ABPM inferior to 130/80mmHg) and electrical left ventricular hypertrophy indexes decreased: R wave in aVL lead of 4±3mm (P=0.031), Sokolow index of 3±3mm (P=0.205), Cornell voltage criterion of 9±7mm (P=0.027) and Cornell product of 1310±1104 (P=0.027).Our results are in accordance with data from other centers. On average blood pressure decreases significantly but important inter individual variations are observed. The procedure seems safe. |
| Databáze: | OpenAIRE |
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