Treatment Outcomes and Predictors of Response in Treatment-Naive HCV Patients Treated with Peginterferon Alfa/Ribavirin in Real-World Italian Clinics: Sub-Analysis from the PROPHESYS Cohort
| Autor: | Antonio, Ascione, Savino, Bruno, Carmine, Coppola, Alessandra, Mangia, Alessandra, Orlandini, Manuela, Schmitz, Barbara, Deodato, Massimo, Puoti |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Liver Cirrhosis Male Time Factors Adolescent Databases Factual Genotype Hepacivirus Interferon alpha-2 Antiviral Agents White People Polyethylene Glycols Young Adult Recurrence Ribavirin Humans Prospective Studies Aged Remission Induction Interferon-alpha Middle Aged Hepatitis C Recombinant Proteins Treatment Outcome Italy Drug Therapy Combination Female |
| Zdroj: | Hepato-gastroenterology. 61(132) |
| ISSN: | 0172-6390 |
| Popis: | Within Europe, Italy has the highest incidence of HCV. PROPHESYS was a large, non-interventional, multinational cohort study of patients treated with peginterferon alfa-2a or -2b/ribavirin for CHC; 22.4% of patients were from Italian centers. This sub-analysis evaluates real-life practice and treatment outcomes in Italy.The PROPHESYS 2 cohort included 1604 HCV mono-infected, treatment-naive patients. All patients were prescribed peginterferon alfa/ribavirin at the discretion of the treating physician according to country-specific requirements.The majority of G1-3 patients were White/Caucasian and 48.4% had HCV G1 infection. Overall, SVR24 rates of 44.9%, 81.4% and 69.1% were achieved in G1-, 2- and 3-infected patients. In G1 patients, SVR24 rates declined with increasing FIB-4 score; this trend was not observed for G2/3-infected patients. Virologic response by Week 2 and 4 was highly predictive of SVR24 (G1: 91.7%, 84.8%; G2: 91.1%, 89.7%; G3: 92.9%, 86.7%, respectively). Absence of virologic response by Week 12 had the highest negative predictive value across genotypes.In Italian patients, a virologic response by Week 2 or 4 was highly predictive of SVR24 across genotypes. These data demonstrate the importance of monitoring on-treatment response to help guide treatment decisions. FIB-4 score correlated well with SVR24 in G1 patients. |
| Databáze: | OpenAIRE |
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