[NEOADJUVANT TARGET THERAPY IN A RENAL-CELL CANCER]
| Autor: | E O, Stakhovskiy, O A, Voylenko, O E, Stakhovskiy, Yu V, Vitruk, P S, Vukalovych, O A, Kononenko |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Sulfonamides Indazoles Indoles Antineoplastic Agents Middle Aged Kidney Nephrectomy Drug Administration Schedule Kidney Neoplasms Neoadjuvant Therapy Tumor Burden Pyrimidines Treatment Outcome Sunitinib Humans Female Pyrroles Tomography X-Ray Computed Carcinoma Renal Cell Aged Neoplasm Staging |
| Zdroj: | Klinichna khirurhiia. (12) |
| ISSN: | 0023-2130 |
| Popis: | There were observed 30 patients (32 tumors), to whom preoperatively for renal-cell cancer (ROC) a neoadjuvant target therapy (NATTH) was conducted. In 19 (66.7%) of them a pazopanib (800 mg per os once a day through 2 mo) was applied, and in 10 (33.3%)--sunitinib (50 mg per os once a day through 28 days, the gap--14 days, repeated course--28 days). The indications for the NATTH conduction were: in 7 (21.9%) patients--a locally--spread RCC with the objective to localize a tumor and to search a further possibility of radical surgical intervention performance, and in 25 (78.1%)--the tumor reduction and searching possibility of the organpreserving treatment conduction. The NATTH conduction in the patients, suffering RCC, have guaranteed a primary pathological focus reduction in 90% of observations, and a partial regression in accordance to the RECIST criteria--in 28.1%. A tumor reduction by (22.9 ± 17.8)% at average have permitted to perform a renal resection in 75% of observations, concerning localized RCC, when indication of preservation of enough functioning renal parenchyma was secured. |
| Databáze: | OpenAIRE |
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