| Autor: |
Rhys, Pritchard, Sara, Rodríguez-Enríquez, Silvia Cecilia, Pacheco-Velázquez, Vuk, Bortnik, Rafael, Moreno-Sánchez, Stephen, Ralph |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Biochemical pharmacology. 154 |
| ISSN: |
1873-2968 |
| Popis: |
Capecitabine induced toxicities such as hand-foot syndrome (HFS) and progression of metastatic cancer are both treatable with concurrent celecoxib as shown in the ADAPT (Activating Cancer Stem Cells from Dormancy And Potentiate for Targeting) trial. In the present study, five commonly used NSAIDs, including celecoxib were compared for their pro-oxidative capacities as cytotoxic drugs against human and mouse metastatic melanoma or breast cancer cells in vitroand the source of cellular ROS production induced by celecoxib was examined in greater detail.Celecoxib was unique among the NSAIDs in that it showed particular potency as a cytotoxic drug against the metastatic cancer cells with ICThese novel findings for direct effects of celecoxib on mitochondria to induce metastatic cancer cell death via a ROS-dependent pro-oxidative mechanism provide supportive evidence for its combinatorial use as a chemosensitizing agent complementing chemotherapies to improve response rates in patients with advanced metastatic cancers. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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