| Autor: |
Haley S, Ball, Misgina B, Girma, Mosufa, Zainab, Iswarduth, Soojhawon, Robin D, Couch, Schroeder M, Noble |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
ACS infectious diseases. 7(11) |
| ISSN: |
2373-8227 |
| Popis: |
The ESKAPE pathogens comprise a group of multidrug-resistant bacteria that are the leading cause of nosocomial infections worldwide. The prevalence of antibiotic resistant strains and the relative ease by which bacteria acquire resistance genes highlight the continual need for the development of novel antibiotics against new drug targets. The methylerythritol phosphate (MEP) pathway is an attractive target for the development of new antibiotics. The MEP pathway governs the synthesis of isoprenoids, which are key lipid precursors for vital cell components such as ubiquinone and bacterial hopanoids. Additionally, the MEP pathway is entirely distinct from the corresponding mammalian pathway, the mevalonic acid (MVA) pathway, making the first committed enzyme of the MEP pathway, 1-deoxy-d-xylulose 5-phosphate reductoisomerase (IspC), an attractive target for antibiotic development. To facilitate drug development against two of the ESKAPE pathogens |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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