| Autor: |
Natasha J, Anstey, Vijayakumar, Kapgal, Shashank, Tiwari, Thomas C, Watson, Anna K H, Toft, Owen R, Dando, Felicity H, Inkpen, Paul S, Baxter, Zrinko, Kozić, Adam D, Jackson, Xin, He, Mohammad Sarfaraz, Nawaz, Aiman, Kayenaat, Aditi, Bhattacharya, David J A, Wyllie, Sumantra, Chattarji, Emma R, Wood, Oliver, Hardt, Peter C, Kind |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Molecular autism. 13(1) |
| ISSN: |
2040-2392 |
| Popis: |
Mutations in the postsynaptic transmembrane protein neuroligin-3 are highly correlative with autism spectrum disorders (ASDs) and intellectual disabilities (IDs). Fear learning is well studied in models of these disorders, however differences in fear response behaviours are often overlooked. We aim to examine fear behaviour and its cellular underpinnings in a rat model of ASD/ID lacking Nlgn3.This study uses a range of behavioural tests to understand differences in fear response behaviour in Nlgn3We observed that, unlike the wildtype, Nlgn3Our findings do not examine what specific cell type in the PAG is likely responsible for these phenotypes. Furthermore, we have focussed on phenotypes in young adult animals, whilst the human condition associated with NLGN3 mutations appears during the first few years of life.We describe altered fear responses in Nlgn3 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full text from SpringerLink