Protein destabilizing agents induce polyreactivity and enhanced immunomodulatory activity in IVIg preparations

Autor:	Iglika K, Djoumerska-Alexieva, Jordan D, Dimitrov, Julia, Nacheva, Srini V, Kaveri, Tchavdar L, Vassilev
Rok vydání:	2009
Předmět:	Disease Models Animal Mice Mice Inbred ICR Antibody Specificity Iron Animals Humans Immunoglobulins Intravenous Reactive Oxygen Species Oxidation-Reduction Shock Septic Chromatography High Pressure Liquid
Zdroj:	Autoimmunity. 42(4)
ISSN:	1607-842X
Popis:	Normal pooled human IVIg are produced using various blood protein fractionation technologies and as a result they may well differ in their biological properties. We have demonstrated that exposure of IVIg, for a period as short as 15 min, to protein-destabilizing agents like acidic pH, ROS or pro-oxidative ferrous ions dramatically increases the panel of recognized Ag including pro-inflammatory cytokines. We now show that exposure of IVIg to ferrous ions modifies some IgG molecules without denaturating them and enhances the protective activity of the preparation in experimental septic shock.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::2e8f4a1cf719e693672c0dcde8ef87ac https://pubmed.ncbi.nlm.nih.gov/19811303 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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