Preclinical Evaluation of a Humanized Antibody Against Common Lymphatic Endothelial and Vascular Endothelial Receptor-1

Autor: Olli, Moisio, Jenni, Virta, Emrah, Yatkin, Heidi, Liljenbäck, Senthil, Palani, Riikka, Viitanen, Maxwell W G, Miner, Vesa, Oikonen, Tuula, Tolvanen, Danielle J, Vugts, Pekka, Taimen, Xiang-Guo, Li, Maija, Hollmén, Sirpa, Jalkanen, Anne, Roivainen
Rok vydání: 2022
Zdroj: Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
ISSN: 1535-5667
Popis: Bexmarilimab is a new humanized monoclonal antibody against common lymphatic endothelial and vascular endothelial receptor-1 (CLEVER-1), and is in clinical trials for macrophage-guided cancer immunotherapy. In addition to cancer, CLEVER-1 is also associated with fibrosis. To facilitate prospective human PET studies, we preclinically evaluated
Databáze: OpenAIRE