| Autor: |
L B, Zavodnik, L I, Sushko, Iu A, Tarasov, K V, Ignatenko, S S, Chumachenko, V A, Ovchinnikov, V, Brzosko, V U, Buko |
| Rok vydání: |
2001 |
| Předmět: |
|
| Zdroj: |
Eksperimental'naia i klinicheskaia farmakologiia. 64(4) |
| ISSN: |
0869-2092 |
| Popis: |
The antioxidant and radioprotector properties of gamma-linolenic acid isolated from the seeds of Borago officialis were studied on rats gamma-irradiated to a dose of 1 Gy. The irradiation caused an increase in the content of malonaldehyde in microsomal liver fraction and disturbed the metabolism of xenobiotics. The administration of gamma-linolenic acid in the form of a commercial drug Neoglandin (daily dose, 150 mg/kg, p.o.; over 1, 3, or 7 days after irradiation reduced the level of lipid peroxidation (for all treatment schedules), normalized the activity of NADPH-oxidase, NADH-oxidase, and NADPH-reductase, and increased the content of cytochromes P-450 and b5 as compared to bothirradiated and control animals. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
