| Autor: |
G, Binson, A, Cariot, N, Venisse, M, Di Maio, S, Rabouan, K, Beuzit, A, Dupuis |
| Jazyk: |
francouzština |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Annales pharmaceutiques francaises. 78(4) |
| ISSN: |
0003-4509 |
| Popis: |
The objective of this study was to quantify parabens intake due to drug administration in neonates during hospitalization following their birth.A monocentric prospective study was performed into a neonatalogy unit to collect all drug prescriptions. An exhaustive list of parabens containing medicines commercialized in France was completed from Theriaque® database. This list was combined with drug prescription to establish an exposure profile to parabens. For each paraben containing medicines, a HPLC-UV assay was performed to determine the average daily intake of paraben received by hospitalized neonates.More than 300 medicines commercialized in France contain at least one paraben. A combination of methylparaben and propylparaben was found in most cases. All hospitalized neonates (n=22) were exposed at least once to methylparaben and propylparaben through medicines while 50 % were exposed to ethylparaben. The average daily intake was higher in term newborns (572,0±249,0 versus 414,6±294,1μg/kg/j for methylparaben) but frequency was higher in prematures (65,0 versus 78,6% for methylparaben) as well as cumutives doses (1421,5±758,8 versus 8618,7±7922,3). These doses are lower than toxicological reference values but these latter do not take into account endocrine disrupting effects of these compounds.These results highlight medicines as a high source of exposure to parabens in hospitalized neonates. It should encourage pharmaceutical companies and health professionnal to prioritize therapeutic cares without parabens. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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