| Autor: |
C, Minguillon, I, Schönborn, A, Reles, U, Bartel, W, Lichtenegger |
| Rok vydání: |
1996 |
| Předmět: |
|
| Zdroj: |
Generaldiagnostic pathology. 141(3-4) |
| ISSN: |
0947-823X |
| Popis: |
Expression of the epidermal growth factor-receptor (EGF-R) and the proliferating cell nuclear antigen (PCNA) was immunohistochemically studied in 75 ovarian cancer samples using formalin-fixed, parafin-embedded tissue. Correlations between these factors and conventional histomorphologic factors were investigated. 44 (58.7%) tumors were EGF-R positive (10% positive cells). 18 tumors (24%) showed a weak EGF-R-expression (or = 50% positivity) and 26 tumors (34.7%) had a strong EGF-R-expression. Expression of EGF-R did not correlate with any of the other prognostic factors investigated. The PCNA-proliferative fraction was classified using the median value (or = 34%/34%) and a categorization in three groups (20%/20%-50%/50%). PCNA-expression showed no correlation with FIGO-stage, histologic tumor type, lymph node-status and EGF-R. However, both PCNA-classifications correlated with the size of the residual tumor (PCNAor = 34%/34%/p = 0.046; PCNA20%/20%-50%/50%/p = 0.086) and the histologic grading (p = 0.076; p = 0.02 respectively). Thus, the PCNA-proliferative fraction might be an additional indicator for tumor aggressiveness and disease outcome. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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