Rheumatoid factor interference with the latex agglutination test for fibrin degradation products

Autor: J E, Rutstein, J R, Holahan, R M, Lyons, R M, Pope
Rok vydání: 1978
Předmět:
Zdroj: The Journal of laboratory and clinical medicine. 92(4)
ISSN: 0022-2143
Popis: The latex agglutination test for FDP is widely employed clinically to aid in the diagnosis of DIC and other conditions. Of sera containing RF, 93% demonstrated positive FDP latex agglutination tests. Reducing agents in all instances destroyed the RF agglutinating capability. Futhermore, 86% of sera positive for FDP and RF became FDP-negative following reduction. Therefore RF was responsible for false-positive FDP latex agglutination tests in the majority of patients. Reduction of patient sera is a rapid, simple method to distinguish a positive FDP test from a false-positive due to RF.
Databáze: OpenAIRE