NMDA receptor antibody encephalitis presenting as Transient Epileptic Amnesia

Autor: Sharon A, Savage, Sarosh R, Irani, M Isabel, Leite, Adam Z, Zeman
Rok vydání: 2018
Předmět:
Zdroj: Journal of Neuroimmunology
ISSN: 1872-8421
Popis: Transient Epileptic Amnesia (TEA) is a subtype of temporal lobe epilepsy, typically presenting in a person's early 60s, and of unknown aetiology. Encephalitis caused by antibodies to NMDA receptors (NMDARE) has not previously been documented in TEA. We describe a 47-year-old male who satisfied criteria for TEA, but given his atypical symptoms, was also screened for autoimmune epilepsy. High levels of serum NMDAR antibodies were found, suggesting NMDARE. Immunosuppressive treatment gradually eliminated the NMDA receptor antibodies. Our case extends the clinical spectrum associated with neuronal cell-surface autoantibodies to include atypical cases of TEA.
Highlights • Transient epileptic amnesia (TEA) is a recently defined syndrome of late life epilepsy. • Its main manifestation is recurrent amnesia, often on awakening. • NMDA receptor encephalitis (NMDARE) has a widening phenotype. • We describe a case of NMDARE presenting as TEA. • TEA is sometime caused by an autoimmune process.
Databáze: OpenAIRE
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