| Autor: |
D E, Wolf, J A, VandenHeuvel, T R, Tyler, R W, Walker, F R, Koniuszy, V, Gruber, B H, Arison, A, Rosegay, T A, Jacob, F J, Wolf |
| Rok vydání: |
1980 |
| Předmět: |
|
| Zdroj: |
Drug metabolism and disposition: the biological fate of chemicals. 8(3) |
| ISSN: |
0090-9556 |
| Popis: |
The incubation of multiply labeled (2H, 3H, 13C, 14C) cambendazole and glutathione with hepatic microsomes from phenobarbital-dosed hamsters results in the formation of polar metabolites. The major metabolite has been characterized by a variety of isotopic, spectrometric, chromatographic, and degradative/synthetic techniques as a glutathione conjugate of cambendazole in which substitution is on the 4-position of the benzimidazole nucleus. The same metabolite is produced by hepatic microsomes from the rat. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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