| Autor: |
Arnd M, Herz, M N, Robertson, J B, Lynch, A, Schmidt, M, Rabin, C, Sherbert, M B, Agy, D, Anderson, S L, Hu, P D, Greenberg, W R, Morton |
| Rok vydání: |
2002 |
| Předmět: |
|
| Zdroj: |
Journal of medical primatology. 31(1) |
| ISSN: |
0047-2565 |
| Popis: |
A model of vertical HIV transmission was developed using oral HIV-2(287) exposure of newborn Macaca nemestrina. The minimal Animal Infectious Dose for this oral route was found to be 10-fold higher than that for atraumatic viral transmission across other mucosal membranes (vaginal/rectal) of juvenile macaques. However, once infection was established, viral replication was rapid and plasma viremia could be detected by reverse-transcriptase polymerase chain reaction and viral co-culture within 1 week following exposure. No animal was resistant to infection and all macaques initially exposed to a subinfectious viral inoculum were subsequently infected by re-exposure of mucosal membranes. Higher viral load during primary infection correlated with a more rapid CD4 depletion; however, all HIV-2(287)-infected animals developed CD4 depletion during the observation period. This animal model can now be used to study early viral replication in the presence and absence of anti-retroviral agents to help identify conditions to reduce vertical HIV transmission in human newborns. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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