| Autor: |
Dong, Zhong, Zhen-shu, Zhang, Yu-hu, Liu, Guo-qing, Zheng, Xiao-yi, Liu, Yang, Lu, Gui-jun, Zhao, An-long, Xu |
| Rok vydání: |
2004 |
| Předmět: |
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| Zdroj: |
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA. 24(2) |
| ISSN: |
1000-2588 |
| Popis: |
On the basis of the knowledge of eukaryotic gene regulation, we modified the method in three aspects: (1) Searching the cis-regulatory modules (CRM) according Fasta or Blast sequence with multiple sequence and low E value, followed by mutual scoring of these sequence with Smith-Waterman algorithms and finally by clustering analysis; (2) Searching the transcription factor-binding site using International Union of Pure and Applied Chemistry, Position-Weight Matrix(PWM) and Dyed method; (3) Designing and implementation of data analysis based on the software in Windows 2000 and UNIX using object-oriented technology. The results of analysis of the major histocompatibility complex gene family show that this procedure may accurately locate the regions that contain some of the CRMs. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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