| Autor: |
Ying, Feng, Chen, Zhong, Jianxiang, Niu, Lin, Zhang, Yang, Zhao, Wen, Wang, Zelan, Hu, Hui, Wang, Ping, He, Qinjie, Ning, JingJing, Xu, Jing, Zheng |
| Rok vydání: |
2018 |
| Zdroj: |
American journal of translational research. 10(11) |
| ISSN: |
1943-8141 |
| Popis: |
Sleeve Gastrectomy (SG), as the most effective bariatric surgery, has been using to chronically lose weight and control glucose metabolism in Type 2 diabetes mellitus patients. However, the underlining mechanism is still unclear. In this study, we performed SG on Zucker diabetes fatty (ZDF) rat and investigated visceral lipid metabolism and energy metabolism. After performance of SG, weight, food intake, fasting plasma glucose (FPG) and oral glucose tolerance teat (OGTT) of rats were measured. Furthermore, whole-body metabolic parameters were obtained through TSE LabMaster. Blood lipid and renal function were analyzed by serum from rats' tail vein. Furthermore, the renal genes expression was either detected by real-time PCR, while western blotting was employed to detect the AKT/PI3K proteins level in rats' kidney. Compared to control groups, body weight of ZDF rats treated with SG were significantly reduced, simultaneously with glucose homeostasis and energy metabolism improved including RER ( |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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