Oxidative stress facilitates cell death by inhibiting Orai1-mediated Ca

Autor:	Hideto, Yamamura, Yoshiaki, Suzuki, Kiyofumi, Asai, Yuji, Imaizumi, Hisao, Yamamura
Rok vydání:	2019
Předmět:	Oxidative Stress Cell Death ORAI1 Protein Blood-Brain Barrier Animals Endothelial Cells Calcium Cattle Hydrogen Peroxide Cells Cultured Acetylcysteine Cell Proliferation
Zdroj:	Biochemical and biophysical research communications. 523(1)
ISSN:	1090-2104
Popis:	Brain capillary endothelial cells (BCECs) form the blood-brain barrier (BBB) and play an essential role in the regulation of its functions. Oxidative stress accumulates excessive reactive oxygen species (ROS) and facilitates the death of BCECs, leading to a dysfunctional BBB. However, the mechanisms underlying the death of BCECs under oxidative stress remain unclear. In the present study, the effects of oxidative stress on cell viability, ROS production, intracellular Ca
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::2d27bfc47f7d38f22307de8333a70e7e https://pubmed.ncbi.nlm.nih.gov/31839216 Zobrazit plný text záznamu Full Text from ScienceDirect