| Autor: |
Ryota, Nakabayashi, Shintaro, Fujihara, Hisakazu, Iwama, Sae, Hamaya, Takaaki, Mizuo, Masahiro, Hirata, Koji, Fujita, Toshiaki, Kono, Daisuke, Namima, Naoki, Fujita, Hiroki, Yamana, Kiyoyuki, Kobayashi, Hideki, Kamada, Asahiro, Morishita, Hideki, Kobara, Masafumi, Ono, Keiichi, Okano, Tsutomu, Masaki |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Anticancer research. 42(8) |
| ISSN: |
1791-7530 |
| Popis: |
Anti-inflammatory drugs, such as aspirin, have attracted attention as anticancer agents that can be applied to standard chemotherapy for pancreatic cancer. This study aimed to examine the antitumour effects and possible fundamental mechanisms of aspirin in pancreatic cancer cells.We appraised the antitumour effects of aspirin on cell proliferation and tumour growth, cell cycle distribution, apoptosis, signalling pathways, angiogenesis-related proteins, and phosphorylated receptor tyrosine kinases (p-RTKs) and identify miRNAs associated with its antitumour effects.Aspirin inhibited cell proliferation in pancreatic cancer cell lines and induced GAspirin inhibited the proliferation of pancreatic cancer cells and induced cell cycle arrest. Aspirin also inactivated GSK-3β but not the p38 MAPK pathway. Thus, aspirin may be used in combination with chemotherapeutic agents for pancreatic cancer. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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