Deep-vein thrombosis and coumarin skin necrosis associated with a factor V inhibitor with lupus-like features

Autor:	P W, Kamphuisen, J, Haan, P C, Rosekrans, F J, Van Der Meer
Rok vydání:	1998
Předmět:	Male Necrosis Coumarins Lupus Coagulation Inhibitor Anticoagulants Factor V Humans Drug Eruptions Thrombophlebitis Aged
Zdroj:	American journal of hematology. 57(2)
ISSN:	0361-8609
Popis:	We report a 71-year-old man who developed deep-vein thrombosis after major surgery. Coumarin skin necrosis developed after starting oral anticoagulant therapy. An inhibitor to factor V (61 Bethesda units) with lupus-like features was found as well as a low protein C level. The occurrence of these very rare findings indicates that despite profound procoagulant inhibition (factor V inhibition and anticoagulant therapy), hypercoagulation can occur.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::2cbc09619a015abffca0e7291df7f632 https://pubmed.ncbi.nlm.nih.gov/9462552 Zobrazit plný text záznamu Plný text