pH-Responsive Theranostic Polymer-Caged Nanobins (PCNs): Enhanced Cytotoxicity and

Autor:	Bong Jin, Hong, Elden P, Swindell, Keith W, Macrenaris, Patrick L, Hankins, Anthony J, Chipre, Daniel J, Mastarone, Richard W, Ahn, Thomas J, Meade, Thomas V, O'Halloran, Sonbinh T, Nguyen
Rok vydání:	2014
Předmět:	Article
Zdroj:	Particleparticle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems. 30(9)
ISSN:	0934-0866
Popis:	A PCN theranostic platform comprises a doxorubicin (DXR)-loaded liposomal core and an acid-sensitive polymer shell that is functionalized with Herceptin and GdIII-based MRI contrast agents. In vitro testing reveals a 14-fold increase in DXR-based cytotoxicity versus a non-targeted analogue and an 120-fold improvement in cellular GdIII–uptake in comparison with clinically approved DOTA-GdIII, leading to significant T1 MRI contrast enhancement.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::2ca79b2619f3bfed1615b36f621feff7 https://pubmed.ncbi.nlm.nih.gov/24516291 Zobrazit plný text záznamu Plný text