The proteolytic activation of interleukin-1 beta

Autor: R, Black, S, Kronheim, P, Sleath, T, Greenstreet, G D, Virca, C, March, T, Kupper
Rok vydání: 1991
Předmět:
Zdroj: Agents and actions. Supplements. 35
ISSN: 0379-0363
Popis: Interleukin-1 beta (IL-1 beta) is released from an inactive precursor by a proteolytic cleavage. A monocytic protease has been identified that appears to be involved in the physiological activation of this cytokine. Two situations have been found in which precursor IL-1 beta exists without the monocytic processing enzyme, and in these cases other proteases, such as neutrophil elastase, cathepsin G and cathepsin L, may be involved in generating the active cytokine.
Databáze: OpenAIRE