H3-receptor regulation of vascular gastrin and somatostatin releases by the isolated rat stomach

Autor:	Bado, A., Moizo, L., Laigneau, J. P., Delwaide, J., Lewin, M. J.
Jazyk:	angličtina
Rok vydání:	1994
Předmět:	Male Dose-Response Relationship Drug Methylhistamines Stomach Histamine Antagonists In Vitro Techniques Rats Histamine Agonists Perfusion Piperidines Gastric Mucosa Gastrins Animals Blood Vessels Receptors Histamine H3 Carbachol Rats Wistar Somatostatin Research Article
Zdroj:	The Yale Journal of Biology and Medicine
ISSN:	1551-4056 0044-0086
Popis:	We have studied the effects of the H3-receptor agonist (R) alpha-methylhistamine [(R) alpha-MeHA] and the H3-receptor antagonist thioperamide (Thiop) on basal- and carbachol-stimulated vascular gastrin release (GR) and somatostatin release (SR) by the isolated rat stomach. Carbachol dose-dependently stimulated and inhibited GR and SR, respectively. Maximal stimulation of GR (500 +/- 112 percent of basal; p < .01), and maximal inhibition of SR (-62 +/- 9 percent under basal; p < .01) were obtained with 1 micron carbachol. Neither (R)alpha-MeHA nor Thiop, up to 10 microns, affected GR. However, SR was dose-dependently enhanced by Thiop (25 +/- 8 percent for 10 microns). Carbachol stimulation of GR was strongly inhibited by Thiop (30 +/- 7 percent for 100 nM and 73 +/- 14 percent for 1 microgram), whereas it was potentiated by (R)alpha-MeHA. Carbachol inhibition of SR was reversed by Thiop and (R)alpha-MeHA. However, the reversal effect of (R)alpha-MeHA was prevented by the CCKB/gastrin receptor antagonist PD134308. These results support H3-receptor regulation of basal and cholinergically-stimulated GR and SR.
Databáze:	OpenAIRE
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