| Autor: |
U U, Akhsianov, N I, Afonin, V B, Troitskiĭ, G V, Sukiasian, A P, Karpov |
| Rok vydání: |
1983 |
| Předmět: |
|
| Zdroj: |
Biulleten' eksperimental'noi biologii i meditsiny. 96(9) |
| ISSN: |
0365-9615 |
| Popis: |
Blood circulation and gas exchange were examined after replacement of blood loss (50 ml/kg bw) in dogs by a preparation containing perfluorocompound (PFC) emulsion (20 v. %) and protein-salt solution (PSS) consisting of isotonic solution of electrolytes and donor's albumin, the final concentration of the latter in the preparation being equal to 5%. Animals with analogous blood loss replaced by PSS alone served as control. Infusion of the preparation under study led to a steady recovery of the main parameters of the hemodynamics disordered as a result of blood loss. Its infusion to experimental animals was followed by a noticeable increase in oxygen blood capacity, provoked a more considerable elevation of pO2 in arterial and venous blood as compared to control. Compensation with PFS emulsion for homeostatic changes that occurred in dogs after blood loss involved a more active oxygen utilization, whereas in controls, a more considerable increase of cardiac output. The study drug is offered as base for a blood substitute-oxygen carrier. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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